WebJun 25, 2024 · Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug delivery. Herein, we report that small interfering RNA (siRNA) effectively coordinates with ligand-free lanthanide nanoparticles (NaGdF4 NPs), and forms siRNA/NaGdF4 spherical nucleic acids (SNA). The coordination is primarily attributed to … WebOct 30, 2007 · Rubenstein has also proposed a branched form of antisense capable of delivering multiple (more than two) oligos simultaneously. Selected oligos would be attached to a membrane soluble scaffold via ester bonds, with release and activation specifically mediated by intracellular esterases . Oligo combinations would be customized by tumor …
Synthesis of branched antisense oligonucleotides having multiple ...
WebIn this design, the branched antisense can efficiently capture siRNA with 3’ overhangs through DNA-RNA hybridization. After being equipped with an active targeting group and an endosomal escape peptide by host-guest interaction, the tailored nucleic acid nanostructure functions efficiently as both delivery carrier and therapeutic cargo, which ... WebJan 30, 2024 · Herein, we report a facile strategy for construction of branched antisense DNA and small interfering RNA (siRNA) co‐assembled nanoplatform for combined gene silencing in vitro and in vivo. In ... market cap of automakers
National Center for Nanoscience and Technology, China
WebJul 19, 2024 · Here, we report a class of bottlebrush polyethylene glycol (PEG)-conjugated antisense oligonucleotides (ASOs) for potent in vivo KRAS depletion. Owing to their highly branched architecture, these molecular nanoconstructs suppress nearly all side effects associated with DNA-protein interactions and substantially enhance the pharmacological ... WebMar 29, 2024 · After cleavage by endogenous RNase H, the branched antisense and biologically active siRNA can be efficiently released for combined gene silencing of tumor … WebCorrection to: Bladder Cancer Progression Is Suppressed Through the Heart and Neural Crest Derivatives Expressed 2‑Antisense RNA 1/microRNA‑93‑5p/Defective in Cullin Neddylation 1 Domain Containing 3 Axis. ... South Branch of Fujian Provincial Hospital, Fuzhou, 350001, China. [email protected]. PMID: 37052864 navarre beach florida newspaper