Structure and function of polo-like kinases
WebApr 12, 2024 · Dysfunction of the WW domain-containing adaptor with coiled-coil, WAC, gene underlies a rare autosomal dominant disorder, DeSanto–Shinawi syndrome (DESSH). DESSH is associated with facial dysmorphia, hypotonia, and cognitive alterations, including attention deficit hyperactivity disorder and autism. How the WAC protein localizes and … WebPolo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis, and cytokinesis. Consistent with the broad range of functions proposed during cell division, Plk is subject to complex temporal and spatial controls. Recent discoveries have revealed the mechanisms of Plk regulation, they target different cellular ...
Structure and function of polo-like kinases
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WebLowery, D. M., Lim, D., & Yaffe, M. B. (2005). Structure and function of Polo-like kinases. Oncogene, 24(2), 248–259. doi:10.1038/sj.onc.1208280 WebNov 30, 2009 · Polo-like kinase (PLK) proteins play critical roles in the control of cell cycle progression, either favoring or inhibiting cell proliferation, and in DNA damage response.
WebJan 1, 2024 · PLKs are multitaskers that regulate a range of processes including DNA replication, DNA damage and repair, maintenance of the genome fidelity, and proliferation and development through the well-coordinated action of signaling cascades during both mitosis and meiosis. WebPolo-like kinases (PLKs) are a family of conserved serine/threonine kinases, which are involved in signal transduction pathways leading to the formation of, and changes in, the mitotic spindle. As such, they are involved in the regulation of cell-cycle progression through G2 and mitosis. These enzymes also activate cyclin-dependent kinase ...
WebJan 10, 2005 · The polo-like kinases (Plks) are a conserved subfamily of Ser/Thr protein kinases that play pivotal roles in regulating various cellular and biochemical events at multiple stages of M phase.
WebFrom a drug discovery perspective, PLK1 offers two functionally distinct, essential, and interconnected target sites in one molecule. These are the ATP binding kinase domain (KD) and the unique Polo Box Domain (PBD), where the interplay between these results in dynamic structural regulation of catalytic activity and sub cellular localization.
WebOct 5, 2012 · Polo-like kinases belong to a family of serine/threonine protein kinases that play a key role in mitotic checkpoint regulation and cell division. Volasertib is a … bridal shop cambridgeWebJan 10, 2005 · Polo-like kinases (Plks) play key roles during multiple stages of mitosis including prophase, metaphase, anaphase, and cytokinesis, in addition to less well … bridal shop cambridgeshireWebMar 18, 2013 · Plk stands for Polo-like kinase. In the 1980s, genetic screens in budding yeast and Drosophila identified several key regulators of mitosis, including the founding … bridal shop camdenWebDec 10, 2012 · Structure of polo-like kinases Plks possess a conserved catalytic kinase domain, which consists of two lobes, each composed of a polypeptide chain. A hinge region connects these two lobes allowing their rotation. ATP molecules can bind at the gap between the two polypeptide chains. The binding pocket structure is highly conserved … bridal shop cameron villageWebPolo-like kinases ( Plks) are regulatory serine/threonin kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. [1] Only one Plk is … bridal shop campbell caWebJan 1, 2024 · The key cell cycle kinases are polo-like kinase (PLK), cyclin-dependent kinase (CDK), and aurora kinases (AURK), which are evolutionarily conserved in eukaryotes from … can the laptop processor be upgradedWebUnder anaerobic conditions, bacteria may utilize nitrates and nitrites as electron acceptors. Sensitivity to nitrous compounds is achieved via several mechanisms, some of which rely … bridal shop campbelltown